Article

CRISPRpas: Programmable regulation of alternative polyadenylation by dCas9

2021-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Well over half of human mRNA genes produce alternative polyadenylation (APA) isoforms that differ in mRNA metabolism due to 3’ UTR size changes or have variable coding potentials when coupled with alternative splicing. Aberrant APA is implicated in a growing number of human diseases. A programmable tool for APA regulation, hence, would be instrumental for understanding how APA events impact biol...

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Literature Corpus work: 16f7f68d-809a-5bba-854c-42491f224d2c
DOI: 10.1101/2021.04.05.438492

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