Article

Spligation enables programmable chimeric RNA generation in living cells

2026-03-06

Abstract excerpt

The ability to precisely modify RNA offers opportunities to manipulate the flow of genetic information and influence transcript stability, localization and translation. RNA-targeting technologies enable RNA knockdown, base editing and trans -splicing, but more extensive transcript changes typically require genome editing or rely on the endogenous splicing machinery. Based on the ability of type III-A CRISPR-Csm c...

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Literature Corpus work: 948a7e10-3cf0-51f6-b046-f00f0f18199d
DOI: 10.64898/2026.03.06.709984

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