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Article

Structural defects in the regulatory particle-core particle interface of the proteasome induce a novel proteasome stress response.

The Journal of biological chemistry - 21 Oct 2011

Park Soyeon, Kim Woong, Tian Geng, Gygi Steven P, Finley Daniel

Abstract excerpt

Proteasomes consist of a 19-subunit regulatory particle (RP) and 28-subunit core particle (CP), an α(7)β(7)β(7)α(7) structure. The RP recognizes substrates and translocates them into the CP for degradation. At the RP-CP interface, a heterohexameric Rpt ring joins to a heteroheptameric CP α ring. Rpt C termini insert individually into the α ring pockets to form a salt bridge with a pocket lysine residue. We report...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21878652
DOI: 10.1074/jbc.M111.285924
PMCID: PMC3196138

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