Blm10 binds to pre-activated proteasome core particles with open gate conformation.

Abstract excerpt

Blm10 is bound to the yeast proteasome core particle, a crucial protease of eukaryotic cells [corrected]. Two gates, at both ends of the CP, control the access of protein substrates to the catalytic cavity of the CP. Normally, substrate access is auto-inhibited by a closed gate conformation unless regulatory complexes are bound to the CP and translocate protein substrates in an ATP-dependent manner. Here, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Enzyme Activation
• Share to Enzyme Stability
• Share to Models, Biological