Article

Mechanistic insights into cold activation and small molecule inhibition of human TRPM8

2026-03-13

Abstract excerpt

Background and purpose: The mechanism of cold temperature activation of the human transient receptor potential melastatin 8 (TRPM8) ion channel is understudied, and how small molecule antagonists inhibit cold as the therapeutically relevant physiologic stimulus is unknown. We demonstrate that key residues in the S1 and S4 helices of the voltage sensor like domain (VSLD) control cold activation, and provide evidenc...

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Literature Corpus work: 5fdac777-68f2-588e-a7e2-50b73d1b3038
DOI: 10.22541/au.177339825.50166190/v1

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