Article

Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3

2025-08-27

Abstract excerpt

The transient receptor potential melastatin 3 (TRPM3) channel is a key mediator of peripheral pain signaling, and pathogenic mutations in TRPM3 are linked to neurodevelopmental delay and epilepsy. Despite the therapeutic promise of TRPM3 modulators, the molecular mechanisms by which ligands modulate channel gating remain poorly understood. Here, we combine cryo-electron microscopy (cryo-EM) with functional analyse...

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Literature Corpus work: 17e6fe83-3918-5111-873b-6978bbf52c35
DOI: 10.1101/2025.08.27.671268

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