Article

Cold Receptor TRPM8 as a target for Migraine-associated Pain and Affective Comorbidities

2025-03-26

Abstract excerpt

<h4>Background</h4> Genetic variations in the Trpm8 gene that encodes the cold receptor TRPM8 have been linked to protection against polygenic migraine, a disabling condition primarily affecting women. Noteworthy, TRPM8 has been recently found in brain areas related to emotional processing, suggesting an unrecognized role in migraine comorbidities. Here, we use mouse behavioural models to investigate the role of...

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Literature Corpus work: a4ef34b0-d18c-5919-98ec-68530f6802bb
DOI: 10.1101/2025.03.25.645275

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