Article

Deep mutational scan of the pore of the cold-sensing TRPM8 channel

2026-05-01

Abstract excerpt

Members of the Transient Receptor Potential (TRP) family of ion channels have a nearly ubiquitous role in human physiology, tuning cell signaling to remarkably diverse physical and chemical stimuli. Although there is extensive structural data on TRP channels, a systematic and unbiased interrogation of structure-function relations in these proteins is required to fully elucidate their mechanisms of function. By foc...

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Literature Corpus work: f6fdce6b-1ea3-5e9d-9ac5-9facdcbe53a8
DOI: 10.64898/2026.04.28.721489

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