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Article

Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.

Molecular pain - 3 Nov 2009

Malkia Annika, Pertusa María, Fernández-Ballester Gregorio, Ferrer-Montiel Antonio, Viana Félix

Abstract excerpt

BACKGROUND: TRPM8 is a non-selective cation channel that belongs to the melastatin subfamily of the transient receptor potential (TRP) ion channels. TRPM8 is activated by voltage, cold and cooling compounds such as menthol. Despite its essential role for cold temperature sensing in mammals, the pharmacology of TRPM8 is still in its infancy. Recently, tyrosine 745 (Y745) was identified as a critical residue for...

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Source

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Identifiers

PMID: 19886999
DOI: 10.1186/1744-8069-5-62
PMCID: PMC2778643

Genes

TRPM8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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