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Article

Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison.

The Journal of biological chemistry - 10 Aug 2018

Pertusa María, Rivera Bastián, González Alejandro, Ugarte Gonzalo, Madrid Rodolfo

Abstract excerpt

In mammals, the main molecular entity involved in innocuous cold transduction is TRPM8. This polymodal ion channel is activated by cold, cooling compounds such as menthol and voltage. Despite its relevance, the molecular determinants involved in its activation by cold remain elusive. In this study we explored the use of TRPM8 orthologs with different cold responses as a strategy to identify new molecular...

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Source

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Identifiers

PMID: 29880642
DOI: 10.1074/jbc.RA118.002256
PMCID: PMC6093233

Genes

TRPM8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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