Article

TRPM8 protein dynamics correlates with ligand structure and cellular function

2025-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Protein dynamics have emerged as a key feature associated with function in various systems. Here, NMR-based studies coupled with computational cheminformatics and cellular function are leveraged to identify a relationship between the human cold and menthol receptor TRPM8 dynamics, chemical structure, and cellular potency. TRPM8 is a validated target for a variety of pain indications but generall...

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Literature Corpus work: 33442373-c596-51a4-b3b8-d495eee65c2e
DOI: 10.1101/2025.05.13.653789

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