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Article

Structural basis for pharmacological modulation of the TRPC6 channel.

eLife - 9 Mar 2020

Bai Yonghong, Yu Xinchao, Chen Hao, Horne Daniel, White Ryan, Wu Xiaosu, Lee Paul, Gu Yan, Ghimire-Rijal Sudipa, Lin Daniel C-H, Huang Xin

Abstract excerpt

Transient receptor potential canonical (TRPC) proteins form nonselective cation channels that play physiological roles in a wide variety of cells. Despite growing evidence supporting the therapeutic potential of TRPC6 inhibition in treating pathological cardiac and renal conditions, mechanistic understanding of TRPC6 function and modulation remains obscure. Here we report cryo-EM structures of TRPC6 in both...

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Identifiers

PMID: 32149605
DOI: 10.7554/eLife.53311
PMCID: PMC7082128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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