Article

A hidden thermal mechanism in inhibitory ligand-gated chloride channels

2026-03-17

Abstract excerpt

Temperature profoundly shapes neural activity, with temperature-sensitive excitatory cation channels serving as key molecular components of thermosensation and neuronal excitability. Here we show that the glutamate-gated chloride channel AVR-14B, a Cys-loop receptor and principal molecular target of the antiparasitic drug ivermectin in the nematode Brugia malayi , exhibits temperature-dependent gating. Applicatio...

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Literature Corpus work: 4b89b1be-fbd3-5116-af17-a749dac254aa
DOI: 10.64898/2026.03.15.711968

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