Article
Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3.
Nature communications - 1 Apr 2026
Bazeli Bahar, Shkumatov Alexander V, Schenck Stephan, Vanherck Jean-Christophe, Janssens Annelies, Spieser Stéphane A H, Marchand Damien, Roelens Robbe, Chaltin Patrick, Marchand Arnaud, Vriens Joris, Voets Thomas, Brunner Janine D
Abstract excerpt
The transient receptor potential melastatin 3 (TRPM3) channel is a key mediator of peripheral pain signaling, and pathogenic mutations in TRPM3 are linked to neurodevelopmental delay and epilepsy. Despite the therapeutic promise of TRPM3 modulators, the molecular mechanisms by which ligands modulate channel gating remain poorly understood. Here, we combine cryo-electron microscopy (cryo-EM) with functional...
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