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Article

Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma.

Leukemia & lymphoma - 1 Nov 2016

Haery Leila, Mussakhan Sultan, Waxman David J, Gilmore Thomas D

Abstract excerpt

Mutations in histone acetyltransferases (HATs) are among the most common mutations in diffuse large B-cell lymphoma (DLBCL). We previously showed that two human DLBCL cell lines, RC-K8 and SUDHL2, express C-terminally truncated, HAT domain-deficient p300 proteins (p300ΔC) that are required for optimal cell proliferation. Microarray analysis of mRNA expression in RC-K8 cells following p300ΔC knockdown shows...

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Share to E1A-Associated p300 Protein
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Modifier

Share to Histone Acetyltransferases

Share to Lymphoma, Large B-Cell, Diffuse

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Share to Proto-Oncogene Proteins c-myc

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Open in PubMed Open full text

Identifiers

PMID: 27003102
DOI: 10.3109/10428194.2016.1160083
PMCID: PMC5045243

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MYC

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