Article

<i>Compartmap</i> enables inference of higher-order chromatin structure in individual cells from scRNA-seq and scATAC-seq

2021-05-18

Abstract excerpt

Single-cell profiling of chromatin structure remains a challenge due to cost, throughput, and resolution. We introduce compartmap to reconstruct higher-order chromatin domains in individual cells from transcriptomic (RNAseq) and epigenomic (ATACseq) assays. In cell lines and primary human samples, compartmap infers higher-order chromatin structure comparable to specialized chromatin capture methods, and identifi...

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Literature Corpus work: 14c4fa23-8cf2-5346-b20f-6df57ae39bfb
DOI: 10.1101/2021.05.17.444465

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