Article
Somatic mosaicism in the buccal mucosa reflects lifestyle and germline risk factors for esophageal squamous cell carcinoma.
Science translational medicine - 30 Apr 2025
Yokoyama Akira, Watanabe Koichi, Inoue Yoshikage, Hirano Tomonori, Tamaoki Masashi, Hirohashi Kenshiro, Kawaguchi Shun, Ishida Yoshihiro, Takeuchi Yasuhide, Kishimoto Yo, Kim Soo Ki, Katada Chikatoshi, Nannya Yasuhito, Seno Hiroshi, Ogawa Seishi, Muto Manabu, Kakiuchi Nobuyuki
Abstract excerpt
Clones harboring cancer driver mutations can expand in normal tissues, known as somatic mosaicism, and can be influenced by age and environmental and germline factors. Somatic mosaicism in the blood predicts the risk of hematological malignancies; however, the relevance of somatic mosaicism to solid tumors remains unclear, in part because of limited sample availability. Lifestyle habits, including alcohol...
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