Article
Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations and mRNA Transcripts.
Cancer discovery - 1 Apr 2026
Yuan Dennis J, Zinno John, Botella Theo, Dhingra Dalia, Wang Shu, Hawkins Allegra G, Swett Ariel, Sotelo Jesus, Raviram Ramya, Hughes Clayton, Potenski Catherine, Godfrey Katharine D, Ainsworth Kara M, Xu Shuzhen, Que Jianwen, Abrams Julian A, Yokoyama Akira, Kakiuchi Nobuyuki, Ogawa Seishi, Landau Dan A
Abstract excerpt
Somatic mosaicism is pervasively observed in human aging, with clonal expansions of cells harboring mutations in recurrently mutated driver genes. Bulk sequencing of tissues captures mutation frequencies but cannot reconstruct clonal architectures nor delineate how driver mutations affect cellular phenotypes. We developed single-cell genotype-to-phenotype sequencing (scG2P) for high-throughput, highly...
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