Article

Somatic mutation inference from single-cell transcriptomics: A survey in the esophagus

2026-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Human somatic tissues accumulate mutations during normal aging. Some of these affect cancer-associated driver genes and confer mutant progenitor cells a competitive advantage that leads to clonal expansions. The human esophageal epithelium exemplifies this phenomenon, becoming a dense mosaic of competing mutant clones by adulthood. However, the phenotypic consequence of those mutations and their...

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Literature Corpus work: 01844e80-206a-5d29-a468-8d5184f422fd
DOI: 10.64898/2026.07.07.737010

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