Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells.

doi:10.1038/s41586-020-2786-7

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Article

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells.

Nature - 1 Oct 2020

Bao Erik L, Nandakumar Satish K, Liao Xiaotian, Bick Alexander G, Karjalainen Juha, Tabaka Marcin, Gan Olga I, Havulinna Aki S, Kiiskinen Tuomo T J, Lareau Caleb A, de Lapuente Portilla Aitzkoa L, Li Bo, Emdin Connor, Codd Veryan, Nelson Christopher P, Walker Christopher J, Churchhouse Claire, de la Chapelle Albert, Klein Daryl E, Nilsson Björn, Wilson Peter W F, Cho Kelly, Pyarajan Saiju, Gaziano J Michael, Samani Nilesh J, Regev Aviv, Palotie Aarno, Neale Benjamin M, Dick John E, Natarajan Pradeep, O'Donnell Christopher J, Daly Mark J, Milyavsky Michael, Kathiresan Sekar, Sankaran Vijay G

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the highest known for cancers1. However, only a limited number of genetic risk loci have been...

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PMID: 33057200
DOI: 10.1038/s41586-020-2786-7
PMCID: PMC7606745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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