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Article

Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions.

Cancer discovery - 1 Mar 2024

Cobaleda Cesar, Godley Lucy A, Nichols Kim E, Wlodarski Marcin W, Sanchez-Garcia Isidro

Abstract excerpt

SUMMARY: The recognition of host genetic factors underlying susceptibility to hematopoietic malignancies has increased greatly over the last decade. Historically, germline predisposition was thought to primarily affect the young. However, emerging data indicate that hematopoietic malignancies that develop in people of all ages across the human lifespan can derive from germline predisposing conditions and are not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38426560
DOI: 10.1158/2159-8290.CD-23-1091
PMCID: PMC10913756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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