Article

Genome-wide analyses of 200,453 individuals yields new insights into the causes and consequences of clonal hematopoiesis

2022-01-06

Abstract excerpt

Clonal hematopoiesis (CH) is one of the most extensively studied somatic mutational phenomena, yet its causes and consequences remain poorly understood. We identify 10,924 individuals with CH amongst 200,453 whole-exome sequenced UK Biobank participants and use their linked genome-wide DNA genotypes to map the landscape of inherited predisposition to CH. We increase the number of European-ancestry genome-wide sign...

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Literature Corpus work: fcc5fa6a-a05f-5494-ac1e-95fe518e2d96
DOI: 10.1101/2022.01.06.22268846

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