Clonal hematopoiesis and hematological malignancy.

Abstract excerpt

Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny driven by somatic mutations in leukemia-associated genes, is a common phenomenon that rises in prevalence with advancing age to affect most people older than 70 years. CH remains subclinical in most carriers, but, in a minority, it progresses to a myeloid neoplasm, such as acute myeloid leukemia, myelodysplastic syndrome, or...

Topics

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• Acute Myeloid Leukemia Research
• Clonal Hematopoiesis
• Hematologic Neoplasms
• Leukemia, Myeloid, Acute
• Mutation