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Article

Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature genetics - 1 Aug 2022

Kar Siddhartha P, Quiros Pedro M, Gu Muxin, Jiang Tao, Mitchell Jonathan, Langdon Ryan, Iyer Vivek, Barcena Clea, Vijayabaskar M S, Fabre Margarete A, Carter Paul, Petrovski Slavé, Burgess Stephen, Vassiliou George S

Abstract excerpt

Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven by somatic driver mutations, affects over a third of people, yet remains poorly understood. Here we analyze genetic data from 200,453 UK Biobank participants to map the landscape of inherited predisposition to CH, increasing the number of germline associations with CH in European-ancestry populations from 4 to 14. Genes at...

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Identifiers

PMID: 35835912
DOI: 10.1038/s41588-022-01121-z
PMCID: PMC9355874

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