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Article

The Genetic Makeup of Myeloproliferative Neoplasms: Role of Germline Variants in Defining Disease Risk, Phenotypic Diversity and Outcome.

Cells - 29 Sept 2021

Masselli Elena, Pozzi Giulia, Carubbi Cecilia, Vitale Marco

Abstract excerpt

Myeloproliferative neoplasms are hematologic malignancies typified by a substantial heritable component. Germline variants may affect the risk of developing a MPN, as documented by GWAS studies on large patient cohorts. In addition, once the MPN occurred, inherited host genetic factors can be responsible for tuning the disease phenotypic presentation, outcome, and response to therapy. This review covered the...

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Identifiers

PMID: 34685575
DOI: 10.3390/cells10102597
PMCID: PMC8534117

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