Article

Germline cancer gene expression quantitative trait loci influence local and global tumor mutations

2022-08-24

Abstract excerpt

Somatic mutations drive cancer development and are relevant to patients’ response to treatment. Emerging evidence shows that variations in the somatic genome can be influenced by the germline genetic background. However, the mechanisms underlying these germline-somatic associations remain largely obscure. We hypothesized that germline variants can influence somatic mutations in a nearby cancer gene (“local impact”...

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Literature Corpus work: 5f00b27c-e079-55c5-bcbf-611cb348729d
DOI: 10.1101/2022.08.23.22279002

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