Germline Cancer Gene Expression Quantitative Trait Loci Are Associated with Local and Global Tumor Mutations.

Abstract excerpt

Somatic mutations drive cancer development and are relevant to patient responses to treatment. Emerging evidence shows that variations in the somatic genome can be influenced by the germline genetic background. However, the mechanisms underlying these germline-somatic associations remain largely obscure. We hypothesized that germline variants can influence somatic mutations in a nearby cancer gene ("local...

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