Article
Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers.
Cancer research - 4 Jan 2023
Namba Shinichi, Saito Yuki, Kogure Yasunori, Masuda Tatsuo, Bondy Melissa L, Gharahkhani Puya, Gockel Ines, Heider Dominik, Hillmer Axel, Jankowski Janusz, MacGregor Stuart, Maj Carlo, Melin Beatrice, Ostrom Quinn T, Palles Claire, Schumacher Johannes, Tomlinson Ian, Whiteman David C, Okada Yukinori, Kataoka Keisuke
Abstract excerpt
Aggregation of genome-wide common risk variants, such as polygenic risk score (PRS), can measure genetic susceptibility to cancer. A better understanding of how common germline variants associate with somatic alterations and clinical features could facilitate personalized cancer prevention and early detection. We constructed PRSs from 14 genome-wide association studies (median n = 64,905) for 12 cancer types by...
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