Article
Germline variants in ATM, BRCA2, other cancer predisposition and novel candidate genes are implicated in glioma risk in adult glioma patients with a familial or personal history of tumors.
Acta neuropathologica - 17 Jan 2026
Brand Frank, Rose Lily S, Akbarzadeh Amir H, Weber Christine A M, Eckert Isabel, Schmidt Gunnar, Auber Bernd, Förster Alisa, Beyer Ulrike, Geffers Robert, Bartels Stephan, Lalk Michael, Polemikos Manolis, Friese Michael, Sabel Michael, Schwenkenbecher Philipp, Kremer Paul, Nabavi Arya, Samii Amir, Lehmann Ulrich, Reifenberger Guido, Krauss Joachim K, Wiese Bettina, Hartmann Christian, Weber Ruthild G
Abstract excerpt
Familial occurrence of gliomas has been reported in around 5% of patients. Studies on the genetic landscape of glioma predisposition are scarce. Here, leukocyte DNA of 213 adult glioma patients with a familial and/or personal tumor history from 206 families was subjected to whole-exome sequencing. Germline variants (GVs) were analyzed using two approaches: (1) GVs in 164 established cancer predisposition genes...
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