Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits.

Nature communications - 4 Jul 2018

Park Solip, Supek Fran, Lehner Ben

Abstract excerpt

The genetic causes of cancer include both somatic mutations and inherited germline variants. Large-scale tumor sequencing has revolutionized the identification of somatic driver alterations but has had limited impact on the identification of cancer predisposition genes (CPGs). Here we present a statistical method, ALFRED, that tests Knudson's two-hit hypothesis to systematically identify CPGs from cancer genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to Exome
Share to Exome Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Histone-Lysine N-Methyltransferase

Share to Histone Methyltransferases

Share to Intracellular Signaling Peptides and Proteins

Share to Loss of Heterozygosity

Source

Open in PubMed Open full text

Identifiers

PMID: 29973584
DOI: 10.1038/s41467-018-04900-7
PMCID: PMC6031629

Genes

NSD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits.PMID 29973584Read ↗

Diverse mediators of cancer predisposition uncovered by germline whole genome sequencing of unexplained familial cancersSemantic proximity Read ↗

Driver and passenger mutations in cancer.Semantic proximity Read ↗

Statistically identifying tumor suppressors and oncogenes from pan-cancer genome-sequencing data.Semantic proximity Read ↗

Cancer Genetic Predisposition and Clinical Applications-A Narrative Review on Germline Genetic Testing, High-Risk Cancer Surveillance and Management.Semantic proximity Read ↗

Common Germline Risk Variants Impact Somatic Alterations and Clinical Features across Cancers.Semantic proximity Read ↗

The whole-genome panorama of cancer driversSemantic proximity Read ↗

COSMIC: High-Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer.Semantic proximity Read ↗

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.Semantic proximity Read ↗

Pathogenic Germline Variants in 10,389 Adult Cancers.Semantic proximity Read ↗

Ancestry-Specific Predisposing Germline Variants in CancerSemantic proximity Read ↗

Expanding cancer predisposition genes with ultra-rare cancer-exclusive human variationsSemantic proximity Read ↗

Patterns and functional implications of rare germline variants across 12 cancer types.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.