Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterizing somatic mutations in ovarian cancer germline risk regions.

Communications biology - 29 Apr 2025

Lai Ping-Hung, Tyrer Jonathan P, Pharoah Paul, Gayther Simon A, Jones Michelle R, Peng Pei-Chen

Abstract excerpt

Epithelial ovarian cancer (EOC) genetics research has been focused on germline or somatic mutations independently. Emerging evidence suggests that the somatic mutational landscape can be shaped by the germline genetic background. In this study, we aim to unravel the role of somatic alterations within EOC germline susceptibility regions by incorporating functional annotations. We investigate somatic events,...

Read the complete abstract on PubMed

Topics

Humans
Female
Germ-Line Mutation
Ovarian Neoplasms
Genetic Predisposition to Disease
Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Copy Number Variations

Mutation

Transcription Factors

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 40301634
DOI: 10.1038/s42003-025-08072-1
PMCID: PMC12041368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterizing somatic mutations in ovarian cancer germline risk regions.PMID 40301634Read ↗

Epithelial ovarian cancer risk: A review of the current genetic landscapeSemantic proximity Read ↗

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes.Semantic proximity Read ↗

Landscape of somatic mutated genes and inherited susceptibility genes in gynecological cancer.Semantic proximity Read ↗

Integrated analysis of germline and somatic variants in ovarian cancerSemantic proximity Read ↗

Exploring the somatic mutational landscape of ovarian cancer in Estonia.Semantic proximity Read ↗

Genomic analyses of germline and somatic variation in high-grade serous ovarian cancerSemantic proximity Read ↗

Genomic Analyses of Germline and Somatic Variation in High-Grade Serous Ovarian CancerSemantic proximity Read ↗

Rare Germline Genetic Variants and the Risks of Epithelial Ovarian CancerSemantic proximity Read ↗

The Clinical Significance of Genetic Variation in Ovarian Cancer.Semantic proximity Read ↗

Comprehensive analysis of germline drivers in endometrial cancer.Semantic proximity Read ↗

Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer.Semantic proximity Read ↗

Germline determinants of the somatic mutation landscape in 2,642 cancer genomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.