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Article

Differential analysis between somatic mutation and germline variation profiles reveals cancer-related genes.

Genome medicine - 25 Aug 2017

Przytycki Pawel F, Singh Mona

Abstract excerpt

A major aim of cancer genomics is to pinpoint which somatically mutated genes are involved in tumor initiation and progression. We introduce a new framework for uncovering cancer genes, differential mutation analysis, which compares the mutational profiles of genes across cancer genomes with their natural germline variation across healthy individuals. We present DiffMut, a fast and simple approach for...

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Identifiers

PMID: 28841835
DOI: 10.1186/s13073-017-0465-6
PMCID: PMC5574113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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