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Ancestry-specific predisposing germline variants in cancer.

Genome medicine - 29 May 2020

Oak Ninad, Cherniack Andrew D, Mashl R Jay, Hirsch Fred R, Ding Li, Beroukhim Rameen, Gümüş Zeynep H, Plon Sharon E, Huang Kuan-Lin

Abstract excerpt

BACKGROUND: Distinct prevalence of inherited genetic predisposition may partially explain the difference of cancer risks across ancestries. Ancestry-specific analyses of germline genomes are required to inform cancer genetic risk and prognosis of diverse populations. METHODS: We conducted analyses using germline and somatic sequencing data generated by The Cancer Genome Atlas. Collapsing pathogenic and likely...

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Identifiers

PMID: 32471518
DOI: 10.1186/s13073-020-00744-3
PMCID: PMC7260738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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