Article

Membrane-proximal external region is a superior target for mediating effector activity of HIV-1 specific chimeric antigen receptor modified T cells

2020-03-11

Abstract excerpt

The use of chimeric antigen receptor modified-T (CAR-T) cells in adoptive immunotherapy has been popularized through recent success in the field of cancer treatment research. CD4ζ CAR, which targets HIV-1-infected cells, has been developed and evaluated in patients. Though well-tolerated for over a decade, efficacy was disappointingly limited. This result encourages us to develop a novel CAR more effective than CD...

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Literature Corpus work: 5ebc4256-bbba-5f9c-8644-43d6714a75c7
DOI: 10.1101/2020.03.11.987610

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