Article

Safety switch optimization enhances antibody-mediated elimination of CAR T cells

2022-08-24

Abstract excerpt

<h4>ABSTRACT</h4> Activation of a conditional safety switch has the potential to reverse serious toxicities arising from the administration of engineered cellular therapies, including chimeric antigen receptor (CAR) T cells. The functionally inert, non-immunogenic cell surface marker derived from human epidermal growth factor receptor (EGFRt) is a promising safety switch that has been used in multiple clinical co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7351facd-76db-5f06-9d0a-6c91f7488ac4
DOI: 10.1101/2022.08.24.505164

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Safety switch optimization enhances antibody-mediated elimination of CAR T cellsDOI 10.1101/2022.08.24.505164Read

Chimeric Antigen Receptor (CAR) T Cells: A Detailed Review of Origins, Engineering, and Therapeutic ImpactSemantic proximity Read

The Evolving Protein Engineering in the Design of Chimeric Antigen Receptor T CellsSemantic proximity Read

Precise Control of Switchable Chimeric Antigen Receptor T Cells Allows Enhanced Safety and Less T Cell ExhaustionSemantic proximity Read

Engineering and Design of Chimeric Antigen ReceptorsSemantic proximity Read

Emerging Cellular Therapies for CancerSemantic proximity Read

Application and Design of Switches Used in CARSemantic proximity Read

Redirecting Specificity of T-Cell Populations For CD19 Using the <i>Sleeping Beauty</i> SystemSemantic proximity Read

CAR-T design: Elements and their synergistic functionSemantic proximity Read

Combinatorial T cell engineering eliminates on-target off-tumor toxicity of CD229 CAR T cells while maintaining anti-tumor activitySemantic proximity Read

De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell librariesSemantic proximity Read

Breaking the Barriers in CAR-T Cell Therapy: Addressing Toxicity, Tumor Microenvironment Suppression, Persistence Challenges, and Trafficking DeficitsSemantic proximity Read

Combination of genetically engineered T cells and immune checkpoint blockade for the treatment of cancerSemantic proximity Read