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Article

Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potency

2022-03-01

Abstract excerpt

<h4>Background</h4> Primary human T cells engineered with chimeric antigen receptors (CARs) ex vivo can be adoptively transferred to treat cancer. CD19-targeting CAR with CD28 costimulatory domain and CD3ζ activation domain have been approved by the US FDA for treating B cell malignancies. <h4>Methods</h4> Here we generated mutation of immunorecpetor tyrosine-based activation motifs (ITAMs) in CD3ζ, namely 1XX C...

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Literature Corpus work
ee27f20b-d0e1-5409-a3ba-9156e748e535
DOI
10.1101/2022.03.01.482445
Open publication

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Balancing activation and costimulation of CAR tunes signaling dynamics and enhances therapeutic potencyDOI 10.1101/2022.03.01.482445
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