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The Application of Nanobody in CAR-T Therapy

8 Feb 2021

Abstract excerpt

Chimeric antigen receptor (CAR) T therapy represents a form of immune cellular therapy with clinical efficacy and a specific target. A typical chimeric antigen receptor (CAR) construct consists of an antigen binding domain, a transmembrane domain, and a cytoplasmic domain. Nanobodies have been widely applied as the antigen binding domain of CAR-T due to their small size, optimal stability, high affinity, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33567640
DOI: 10.3390/biom11020238

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