Article

Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) construct

2023-10-26

Abstract excerpt

Chimeric antigen receptor (CAR)-T cells have demonstrated clinical potential, but current receptors still need improvements to be successful against chronic HIV infection. In this study, we address some requirements of CAR motifs for strong surface expression of a novel anti-HIV CAR by evaluating important elements in the extracellular, hinge, and transmembrane (TM) domains. When combining a truncated CD4 extracel...

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Identifiers and source

Literature Corpus work: 7e41bec1-183c-5b5c-a09a-2eeb852d5334
DOI: 10.1101/2023.10.25.563930

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Extracellular domain, hinge, and transmembrane determinants affecting surface CD4 expression of a novel anti-HIV chimeric antigen receptor (CAR) constructDOI 10.1101/2023.10.25.563930Read

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