Article

Safe Redosable Low-Immunogenic In Vivo CAR-T Therapy for B Cell Malignancies and Solid Tumors

2026-07-01

Abstract excerpt

In vivo CAR-T cell therapy eliminates manufacturing complexities associated with ex vivo autologous approaches, but safety concerns have limited adoption. We developed viroVbot, a next-generation in vivo CAR-T platform, by combining computational immunogenicity prediction (CIMMEX TM ) with envelope engineering. Screening 22,562 glycoprotein sequences, we identified 641 vesiculovirus homologs, from which we select...

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Literature Corpus work: cb1d21b4-da1e-502a-9f1f-aa3bd0119c61
DOI: 10.64898/2026.06.30.735484

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