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Article

Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.

Molecular and cellular biology - 1 Jul 2008

Guo Zhigang, Qian Limin, Liu Ren, Dai Huifang, Zhou Mian, Zheng Li, Shen Binghui

Abstract excerpt

Despite the wealth of information available on the biochemical functions and our recent findings of its roles in genome stability and cancer avoidance of the structure-specific flap endonuclease 1 (FEN1), its cellular compartmentalization and dynamics corresponding to its involvement in various DNA metabolic pathways are not yet elucidated. Several years ago, we demonstrated that FEN1 migrates into the nucleus in...

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Source

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Identifiers

PMID: 18443037
DOI: 10.1128/MCB.00200-08
PMCID: PMC2447149

Genes

FEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.PMID 18443037Read ↗

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