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Article

Evidence that the DNA mismatch repair system removes 1-nucleotide Okazaki fragment flaps.

The Journal of biological chemistry - 2 Oct 2015

Kadyrova Lyudmila Y, Dahal Basanta K, Kadyrov Farid A

Abstract excerpt

The DNA mismatch repair (MMR) system plays a major role in promoting genome stability and suppressing carcinogenesis. In this work, we investigated whether the MMR system is involved in Okazaki fragment maturation. We found that in the yeast Saccharomyces cerevisiae, the MMR system and the flap endonuclease Rad27 act in overlapping pathways that protect the nuclear genome from 1-bp insertions. In addition, we...

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Identifiers

PMID: 26224637
DOI: 10.1074/jbc.M115.660357
PMCID: PMC4591796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence that the DNA mismatch repair system removes 1-nucleotide Okazaki fragment flaps.PMID 26224637Read ↗

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