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Article

Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesis.

The Journal of biological chemistry - 5 Dec 2008

Stith Carrie M, Sterling Joan, Resnick Michael A, Gordenin Dmitry A, Burgers Peter M

Abstract excerpt

Okazaki fragment maturation to produce continuous lagging strands in eukaryotic cells requires precise coordination of strand displacement synthesis by DNA polymerase delta (Pol delta) with 5.-flap cutting by FEN1(RAD27) endonuclease. Excessive strand displacement is normally prevented by the 3.-exonuclease activity of Pol delta. This core maturation machinery can be assisted by Dna2 nuclease/helicase that...

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Identifiers

PMID: 18927077
DOI: 10.1074/jbc.M806668200
PMCID: PMC2590699

Genes

FEN1
PIF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Flexibility of eukaryotic Okazaki fragment maturation through regulated strand displacement synthesis.PMID 18927077Read ↗

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