Article

PARP Inhibition Impedes the Maturation of Nascent DNA Strands During DNA Replication

2021-07-03

Abstract excerpt

PARP1 is implicated in the detection and repair of unligated Okazaki fragment intermediates, highlighting these structures as a potential source of genome breakage induced by PARP inhibition. In agreement with this, we show here that PARP1 activity is greatly elevated in chicken and human S phase cells in which FEN1 nuclease is genetically deleted, and that PARP activity is highest tens of kilobases behind DNA rep...

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Literature Corpus work: 7dd7eede-2663-5bb9-9534-f6a67ff6d7e8
DOI: 10.1101/2021.07.03.450982

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