Article
XPF mediates 3' flap processing for FEN1-independent Okazaki fragment maturation.
Nucleic acids research - 20 May 2026
Li Kejiao, Yang Feng, Wang Yingying, Shi Guojun, Wang Yixing, Liu Yunhao, Yan Yao, Lei Yi, Zhou Main, Sun Haitao, Zheng Li, Shen Binghui
Abstract excerpt
Okazaki fragment maturation (OFM), the process that removes RNA-DNA primers, is a major source of DNA replication stress and mutations. It involves Polδ-mediated DNA strand displacement synthesis that produces 5' flaps, FEN1-mediated 5' flap cleavage, and LIG1-catalyzed nick ligation. Recently, we discovered that under hyperthermal stress conditions, yeast cells convert 5' flaps into 3' flaps, which are degraded...
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