Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jul 2005

Shen Binghui, Singh Purnima, Liu Ren, Qiu Junzhuan, Zheng Li, Finger L David, Alas Steve

Abstract excerpt

Flap EndoNuclease-1 (FEN-1) is a multifunctional and structure-specific nuclease involved in nucleic acid processing pathways. It plays a critical role in maintaining human genome stability through RNA primer removal, long-patch base excision repair and resolution of dinucleotide and trinucleotide repeat secondary structures. In addition to its flap endonuclease (FEN) and nick exonuclease (EXO) activities, a new...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Muscular Diseases
Share to Amino Acid Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endonucleases

Share to Exonucleases

Share to Flap Endonucleases

Share to Nucleic Acids

Share to Proliferating Cell Nuclear Antigen

Share to Protein Processing, Post-Translational

Source

Identifiers

PMID: 15954100
DOI: 10.1002/bies.20255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.PMID 15954100Read ↗

Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways.Semantic proximity Read ↗

The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.Semantic proximity Read ↗

Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.Semantic proximity Read ↗

Exonuclease 1 and its versatile roles in DNA repair.Semantic proximity Read ↗

Human Apurinic/Apyrimidinic Endonuclease 1Semantic proximity Read ↗

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks.Semantic proximity Read ↗

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNASemantic proximity Read ↗

Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in CancerSemantic proximity Read ↗

A Bibliometric Analysis of Researches on Flap Endonuclease 1 From 2005 to 2019Semantic proximity Read ↗

The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.Semantic proximity Read ↗

Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.Semantic proximity Read ↗

Role of human DNA2 (hDNA2) as a potential target for cancer and other diseases: A systematic review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.