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Article

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA

1 Jun 1996

Abstract excerpt

In eukaryotic cells, a 5' flap DNA endonuclease activity and a ds DNA 5'-exonuclease activity exist within a single enzyme called FEN-1 [flap endo-nuclease and 5(five)'-exo-nuclease]. This 42 kDa endo-/exonuclease, FEN-1, is highly homologous to human XP-G, Saccharomyces cerevisiae RAD2 and S.cerevisiae RTH1. These structure-specific nucleases recognize and cleave a branched DNA structure called a DNA flap, and...

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Identifiers

PMID: 8668533
DOI: 10.1093/nar/24.11.2036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Processing of branched DNA intermediates by a complex of human FEN-1 and PCNAPMID 8668533Read ↗

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