Article

Human proton channels accumulate in cholesterol dependent membrane domains via direct interaction with stomatin

2023-10-01

Abstract excerpt

Many membrane proteins are modulated by cholesterol. Here we report strong effects of cholesterol depletion and restoration on the human voltage gated proton channel, hH V 1 in excised patches but negligible effects in whole-cell configuration. Despite the presence of a putative cholesterol binding site, a CARC domain in the human voltage gated proton channel, hH V 1, mutation of this domain did not affect chole...

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Literature Corpus work: 5e866616-cb7f-5797-9bcf-bf7ecb6c7baa
DOI: 10.1101/2023.09.28.560017

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