Mutations in an intracellular vestibule that bifurcates from the pore of ClC-1 chloride ion channels affect anion permeation

Abstract excerpt

The ubiquitous CLC protein superfamily consists of channels, that permit passive diffusion of Cl ions across biological membranes, and pumps, that can actively transport Cl ions against their electrochemical gradient; yet, puzzlingly, both types share a strongly conserved Cl ion transport pathway comprised of three consecutive binding sites. This raises the question; how does the same pathway support passive diffu...

Topics

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• Amino Acid Substitution
• Chloride Channels
• Chlorides
• Glutamic Acid
• Ion Channel Gating
• Ion channel regulation and function
• Models, Molecular
• Mutation

Identifiers and source

Literature Corpus work

130526cc-2de5-502d-bc37-cb2abc435548

DOI

10.1101/2020.11.01.364042