Constitutive signaling by the C-terminal fragment of polycystin-1 is mediated by a tethered peptide agonist

Abstract excerpt

<h4>ABSTRACT</h4> Mutation of the PKD1 gene, encoding polycystin-1 (PC1), is the primary cause of autosomal dominant polycystic kidney disease. PC1 is an 11-transmembrane domain protein that binds and modulates the activity of multiple heterotrimeric G protein families and is thought to function as a non-canonical G protein-coupled receptor (GPCR). PC1 shares a conserved G PCR a utoproteolysis in ducing [GAIN...

Topics

Open a Topic to create a Post that cites this publication.

• Biomedical Research and Pathophysiology
• Genetic and Kidney Cyst Diseases
• Microtubule and mitosis dynamics
• Mutation
• Polycystic Kidney, Autosomal Dominant
• Receptors, G-Protein-Coupled
• Signal Transduction
• TRPP Cation Channels

Identifiers and source

Literature Corpus work

3dfefa6c-d05f-5a86-a947-311ff9bbab33

DOI

10.1101/2021.08.20.457171