Article

Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes

2024-05-06

Abstract excerpt

<h4>ABSTRACT</h4> The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride channel whose dysfunction leads to intracellular accumulation of chloride ions, dehydration of cell surfaces, and subsequent damage to airway and ductal organs. Beyond its function as a chloride channel, interactions between CFTR, ENaC, and SLC transporter family membrane proteins and cytoplasmic proteins, including cal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 31b65067-5c41-562e-b2eb-96161414a461
DOI: 10.1101/2024.05.03.592454

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranesDOI 10.1101/2024.05.03.592454Read

Macromolecular interactions and ion transport in cystic fibrosis.Semantic proximity Read

Lipid-driven CFTR clustering is impaired in cystic fibrosis and restored by corrector drugs.Semantic proximity Read

Revisiting CFTR Interactions: Old Partners and New Players.Semantic proximity Read

CFTR processing, trafficking and interactions.Semantic proximity Read

Functional Consequences of CFTR Interactions in Cystic Fibrosis.Semantic proximity Read

CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partnersSemantic proximity Read

CFTR: a hub for kinases and crosstalk of cAMP and Ca2+.Semantic proximity Read

The bidirectional relationship between CFTR and lipids.Semantic proximity Read

Structural mechanisms of CFTR function and dysfunctionSemantic proximity Read

A Proteomic Survey of the Cystic Fibrosis Transmembrane Conductance Regulator Surfaceome.Semantic proximity Read

Comprehensive mapping of Cystic Fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding siteSemantic proximity Read

Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.Semantic proximity Read